Serine, a non-essential amino acid synthesized by the body, participates in various biological functions crucial for overall well-being, including skin health. Its significance in maintaining optimal skin condition is notable, particularly in regulating moisture levels. As part of natural moisturizing factors (NMFs) like pyrrolidone carboxylic acid and urea, serine aids in attracting and retaining water in the skin, fostering hydration and a vibrant complexion. Moreover, serine contributes to the synthesis of ceramides, pivotal for reinforcing the skin’s barrier function. Ceramides play a vital role in upholding skin integrity, preventing moisture loss, and shielding against external aggressors. By bolstering the skin’s innate defense mechanisms, serine supports resilient and healthy skin. Additionally, serine is involved in the intricate process of wound healing.